β-Adrenergic Signaling Inhibits G q -Dependent Protein Kinase D Activation by Preventing Protein Kinase D Translocation
نویسندگان
چکیده
منابع مشابه
β-adrenergic signaling inhibits Gq-dependent protein kinase D activation by preventing protein kinase D translocation.
RATIONALE Both β-adrenergic receptor (β-AR) and Gq-coupled receptor (GqR) agonist-driven signaling play key roles in the events, leading up to and during cardiac dysfunction. How these stimuli interact at the level of protein kinase D (PKD), a nodal point in cardiac hypertrophic signaling, remains unclear. OBJECTIVE To assess the spatiotemporal dynamics of PKD activation in response to β-AR s...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2014
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.114.303870